Theta-gamma phase-amplitude coupling: physiological basics, analysis methods, and perspectives of translation into clinical practice

Studying rhythmic neural synchronization (cross-frequency coupling in various ranges) is an emerging topic present-day neurophysiology. One of the best-studied cross-frequency couplings theta-gamma phase-amplitude that contributes to cognitive function and may vary patients with several conditions associated impairment. Changes can be registered a wide range diseases decline.
 The review covers physiological basics coupling, its registration calculation, correlation test results healthy volunteers, changes patients. We have discussed preliminary studies frequency-dependent non-invasive brain stimulation based on coupling.